Synthetic Communications

Microwave-assisted NBS bromination of p-iminotoluenes: Preparation of new alcohol, mercapto, and amino protection groups

SK Upadhyay, BS Jursic

Index: Upadhyay, Sunil K.; Jursic, Branko S. Synthetic Communications, 2011 , vol. 41, # 21 p. 3177 - 3185

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Citation Number: 2

Abstract

Abstract A simple, efficient, safe, high-yielding and rapid microwave-assisted method for the preparation of protected p-bromomethyl and p-dibromomethylanilines was developed as new alcohol, thiol, and amine protection groups. The procedure involves microwave- assisted N-bromosuccinimide (NBS) radical bromination of readily available N-protected p- toluidine. The microwave-assisted radical bromination was found to be superior to the ...