Journal of the American Chemical Society

Meta bridging reactions of electron-deficient aromatics. I. One-step synthesis of the 6, 7-benzomorphan ring system. Facile preparation of potential narcotic …

RR Bard, MJ Strauss

Index: Bard,R.R.; Strauss,M.J. Journal of the American Chemical Society, 1975 , vol. 97, # 13 p. 3789 - 3798

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Citation Number: 24

Abstract

Abstract: Reactions of a series of amidines with electron-deficient benzenes and naphthalenes have been shown to yield addition products. In certain cases, cyclization of the initial adducts occurs to yield the 6, 7-benzomorphan ring system. The reaction is a new and useful preparation of such structures which, when appropriately functionalized, may have useful narcotic analgesic and antagonist activity. The reactivity of the amidine u ...