Chemical Communications

A convenient stereoselective synthesis of trifluoromethyl-substituted polyfunctionalized cyclopropane: synthesis of (±)-trans-trifluoronorcoronamic acid

B Jiang, F Zhang, W Xiong

Index: Jiang, Biao; Zhang, Fangjiang; Xiong, Wennan Chemical communications (Cambridge, England), 2003 , # 4 p. 536 - 537

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Abstract

Trifluoromethylated polyfunctionalized cyclopropanes were obtained in high stereoselectivity by reacting 2-bromo-3, 3, 3-trifluoropropene (BrTFP) with active methylenes. This novel method was further applied to the synthesis of (±)-trans- trifluoronorcoronamic acid.