4-Hydroxyquinol-2-ones. 87. Unusual Synthesis of 1-R-4-Hydroxy-2-oxo-1, 2-dihydroquinoline-3-carboxylic Acid Pyridylamides

…, SV Slobodzyan, VB Rybakov, VV Chernyshev

Index: Ukrainets; Sidorenko; Slobodzyan; Rybakov; Chernyshev Chemistry of Heterocyclic Compounds, 2005 , vol. 41, # 9 p. 1158 - 1166

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Abstract

Abstract 4-Chloro-2-oxo-1, 2-dihydroquinoline-3-carboxylic acids and their esters react with aminopyridines in refluxing DMF to give the corresponding 4-hydroxy-2-oxo-1, 2- dihydroquinoline-3-carboxylic acid pyridylamides. Their structures were proved by 1 H NMR and mass spectroscopy, counter synthesis, and by X-ray analysis. A possible mechanism is proposed for the indicated chemical reaction.

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