Acylaminoacetyl derivatives of active methylene compounds. 1. The cyclization of the benzoylaminoacetyl derivatives to α??substituted tetramic acids

O Igglessi??Markopoulou…

Index: Igglessi-Markopoulou, Olga; Sandris, Constantine Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 883 - 890

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Citation Number: 17

Abstract

Abstract Hippuric acid was converted to α-Y-substituted tetramic acids (Y=-CN,-CO 2 R and- COCH 3) according to the following general scheme of reactions: a) preparation of the hippuric acid chloride or of its p-nitrophenyl ester; b) C-acylation of an active methylene compound Y-CH 2-CO 2 R using the acid chloride or the active ester; and c) intramolecular condensation of the C-acylation compound to an α-Y-substituted tetramic acid. The ...