[125 I]-N-[(3-Azido-5-iodo) benzyl] dantrolene and [125 I]-N-{[3-Iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)] benzyl} dantrolene: photoaffinity probes specific for the …

T Hosoya, H Aoyama, T Ikemoto, T Hiramatsu…

Index: Hosoya, Takamitsu; Aoyama, Hiroshi; Ikemoto, Takaaki; Hiramatsu, Toshiyuki; Kihara, Yasutaka; Endo, Makoto; Suzuki, Masaaki Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 22 p. 3263 - 3265

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Citation Number: 14

Abstract

In order to capture and identify key molecules that regulate the release of Ca2+ from the sarcoplasmic reticulum (SR) of skeletal muscle, we designed specific photoaffinity probes based on the structural modification of dantrolene. Thus, GIF-0082 and GIF-0276 possessing azido-and trifluoromethyldiazirinyl-benzyl groups, respectively, at the hydantoin moiety were found to have a highly selective inhibitory effect on physiological Ca2+ ...