An effective one-pot synthesis of 5-substituted tetronic acids

…, F García-Tellado, JJ Marrero-Tellado…

Index: Aragon, David Tejedor; Lopez, Gloria V.; Garcia-Tellado, Fernando; Marrero-Tellado, Jose Juan; De Armas, Pedro; Terrero, David Journal of Organic Chemistry, 2003 , vol. 68, # 8 p. 3363 - 3365

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Citation Number: 29

Abstract

An expeditious one-pot synthesis of 5-substituted tetronic acids from aldehydes and terminal conjugated alkyne as starting materials is described. The entire process embodies two consecutive chemical events: a catalytic domino reaction to build the 1, 3-dioxolane scaffolds 5 and a two-step acid-catalyzed trans-acetalization-lactonization reaction to furnish the tetronic acid derivatives 6.