Synlett

A convenient approach to (-)-8-epi-swainsonine

AJ Murray, PJ Parsons

Index: Murray, Adrian J.; Parsons, Philip J. Synlett, 2006 ,  # 9  p. 1443 - 1445

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Citation Number: 5

Abstract

Abstract A novel and efficient synthesis of (-)-8-epi-swainsonine (2) is reported. Face- selective diol formation from the bicyclic alkene 3 followed by a stereoselective vinylation of the aldehyde and ring-closing metathesis gave the indolizidine ring system, which was converted into (-)-8-epi-swainsonine (2).