Effect of nifedipine on alkaloid accumulation in Catharanthus roseus cell cultures
JM Merillon, D Liu, Y Laurent, M Rideau, C Viel
Index: Merillon, J. M.; Liu, D.; Laurent, Y.; Rideau, M.; Viel, C. Phytochemistry (Elsevier), 1992 , vol. 31, # 5 p. 1609 - 1612
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Citation Number: 12
Abstract
Abstract The effect of nifedipine on both alkaloid accumulation and calcium uptake in Catharanthus roseus cell cultures was investigated. It was shown that nifedipine inhibited ajmalicine accumulation through a mechanism other than blocking of the calcium channel uptake. Moreover, nifedipine was biotransformed into its 4-(2′-aminophenyl)-pyridine derivative.
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