Convenient Synthesis of Difluoromethyl Alcohols from Both Enolizable and Non??Enolizable Carbonyl Compounds with Difluoromethyl Phenyl Sulfone

GK Surya Prakash, J Hu, Y Wang…

Index: Prakash, G.K.Surya; Hu, Jinbo; Wang, Ying; Olah, George A. European Journal of Organic Chemistry, 2005 , # 11 p. 2218 - 2223

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Citation Number: 24

Abstract

Abstract A general and efficient nucleophilic difluoromethylation of carbonyl compounds (both enolizable and non-enolizable aldehydes and ketones) has been achieved by using a nucleophilic (phenylsulfonyl) difluoromethylation-reductive desulfonylation strategy. Difluoromethyl phenyl sulfone acts as a difluoromethyl anion (“CF 2 H–”) equivalent.(© Wiley- VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005)