Stereospecific synthesis and bio-activity of novel β 3-adrenoceptor agonists and inverse agonists

…, E Santandrea, L Bleve, P Vitale, NA Colabufo…

Index: Perrone, Maria Grazia; Santandrea, Ernesto; Bleve, Laura; Vitale, Paola; Colabufo, Nicola Antonio; Jockers, Ralf; Milazzo, Ferdinando Maria; Sciarroni, Anna Floriana; Scilimati, Antonio Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 5 p. 2473 - 2488

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Citation Number: 17

Abstract

Since it is widely distributed into the body, β3-adrenoceptor is becoming an attractive target for the treatment of several pathologies such as obesity, type 2 diabetes, metabolic syndrome, cachexia, overactive bladder, ulcero-inflammatory disorder of the gut, preterm labour, anxiety and depressive disorders, and heart failure. New compounds belonging to the class of arylethanolamines bearing one or two stereogenic centres were prepared in ...