Tetrahedron

Enantioselective route to key intermediates in the synthesis of carbocyclic phosphoribosyltransferase transition state analogues

M Ahmadian, NK Khare, JM Riordan, AE Klon…

Index: Ahmadian, Mohammad; Khare, Naveen K.; Riordan, James M.; Klon, Anthony E.; Borhani, David W. Tetrahedron, 2001 , vol. 57, # 50 p. 9899 - 9909

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Citation Number: 6

Abstract

The enantioselective preparation of key intermediates in the synthesis of transition state analogues of hypoxanthine-guanine phosphoribosyltransferase,(1S, 2S, 3R, 4R)-4- acetoxymethyl-1-bromomethyl-2, 3-isopropylidenedioxy-1-toluenesulfonamidocyclopentane (3a) and the 4-nitrobenzenesulfonamido analogue (3b), are described.