Design and synthesis of new 7, 8-dimethoxy-α-naphthoflavones as CYP1A1 inhibitors

JH Cui, D Hu, X Zhang, Z Jing, J Ding, RB Wang…

Index: Cui, Jia-Hua; Hu, Dagula; Zhang, Xu; Jing, Zheng; Ding, Jing; Wang, Ru-Bing; Li, Shao-Shun Chinese Chemical Letters, 2013 , vol. 24, # 3 p. 215 - 218

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Citation Number: 6

Abstract

Abstract The flavonoids as inhibitors of CYP1A1 exhibit chemopreventive effects against certain procarcinogens and have been considered as the promising cancer preventive agents. A series of novel 7, 8-dimethoxy-α-naphthoflavones as the substrate analogs were designed and prepared. The enzyme assay suggested that all of these new flavones were stronger inhibitors of CYP1A1 than the lead compound α-naphthoflavone. Among the ...