The use of radical decarboxylation in the preparation of 1-methylcarbapenem antibiotic precursors from D-glucosamine

…, DHR Barton, MC Caballero, SD Gero, M Grande…

Index: Anaya; Barton; Cruz Caballero; Gero; Grande; Laso; Hernando Tetrahedron Asymmetry, 1994 , vol. 5, # 11 p. 2137 - 2140

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Citation Number: 12

Abstract

Abstract The stereocontrolled synthesis of optically active 1-methylcarbapenams has been performed by radical cyclization and radical decarboxylation. 1, 3, 4-Trisubstituted-2- azetidinones, prepared by the Staudinger reaction with D-glucosamine as chiral auxiliary and sorbic acid were used as starting materials.