The Journal of organic chemistry

Tandem bis-aldol reaction of ketones: a facile one-pot synthesis of 1, 3-dioxanes in aqueous medium

V Polshettiwar, RS Varma

Index: Polshettiwar, Vivek; Varma, Rajender S. Journal of Organic Chemistry, 2007 , vol. 72, # 19 p. 7420 - 7422

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Citation Number: 85

Abstract

A novel tandem bis-aldol reaction of ketone with paraformaldehyde catalyzed by polystyrenesulfonic acid in aqueous medium delivers 1, 3-dioxanes in high yield. This one- pot, operationally simple microwave-assisted synthetic protocol proceeds efficiently in water in the absence of organic solvent, with excellent yield.