European journal of medicinal chemistry

Carbonic anhydrase inhibitors. Part 61. Quantum chemical QSAR of a group of benzenedisulfonamides

BW Clare, CT Supuran

Index: Clare, Brian W.; Supuran, Claudiu T. European Journal of Medicinal Chemistry, 1999 , vol. 34, # 6 p. 463 - 474

Full Text: HTML

Citation Number: 74

Abstract

The synthesis of a large group of benzenesulfonamides containing both a primary and secondary sulfonamide moiety is described. These compounds are powerful inhibitors of several isozymes of the enzyme carbonic anhydrase. Separate QSAR's are given for inhibition of three of these isozymes, using descriptors mainly derived from molecular orbital calculations by the semiempirical AM1 method. Activity was found to depend on ...