Tetrahedron letters

Towards the synthesis of osteoclast inhibitor SB-242784

JJ Conde, M McGuire, M Wallace

Index: Conde, Jose J.; McGuire, Michael; Wallace, Michael Tetrahedron Letters, 2003 , vol. 44, # 15 p. 3081 - 3084

Full Text: HTML

Citation Number: 13

Abstract

Osteoclast inhibitor SB-242784 (1) was prepared from pivotal indol intermediate 4. A 'Stille'cross coupling of organotin 2c with bromo acrylate 11 afforded diene 12 which was also obtained via a reduction–isomerization process of enyne 16. Bromoamide 3 was prepared from the corresponding acid 7 which was readily obtained from bromopyruvic acid.