Journal of medicinal chemistry

Bromomesaconic and bromocitraconic acids. Potential active site labeling reagents for dicarboxylic acid metabolizing enzymes

RA Laursen, WC Shen, KG Zahka

Index: Laursen; Shen; Zahka Journal of medicinal chemistry, 1971 , vol. 14, # 17 p. 619 - 621

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Citation Number: 11

Abstract

Chemistry.-Two synthetic pathways to 4 were devised, the first providing an unambiguous synthesis of 4, and the second a convenient route to the 14C-labeled material as well as the isomer 11. Bromination of di-terl-butyl mesaconate (2), prepared by the action of NaO-tert-Bu