A novel series of potent cytotoxic agents targeting G2/M phase of the cell cycle and demonstrating cell killing by apoptosis in human breast cancer cells

S Mandal, G Bérubé, É Asselin, I Mohammad…

Index: Mandal, Soma; Berube, Gervais; Asselin, Eric; Mohammad, Iqbal; Richardson, Vernon J.; Gupta, Atul; Pramanik, Saroj K.; Williams, Arthur L.; Mandal, Sanat K. Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 17 p. 4955 - 4960

Full Text: HTML

Citation Number: 21

Abstract

Breast cancer, a leading cause of mortality in women, warrants the development and biological evaluation of new anticancer agents. A novel series of thiopyridine triazine derivatives was synthesized and investigated in the human breast cancer cell line, MDA-MB- 468. SM40, the most potent derivative, induced a G2/M arrest and apoptosis with a possible involvement of p53. The cytotoxicity of SM40 was also examined against the NCI 60 cell ...