Process improvements for the manufacture of tenofovir disoproxil fumarate at commercial scale

DH Brown Ripin, DS Teager, J Fortunak…

Index: Organic Process Research and Development, , vol. 14, # 5 p. 1194 - 1201

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Citation Number: 35

Abstract

... Organic Process Research & Development. ... Two practical alternatives to TMSBr for the execution of this process are available. Either aqueous HBr(7) or the use of TMSCl in the presence of NaBr in organic solvent(6) was preferred for process stage 2b. ...