Australian journal of chemistry

The Chemistry of 5-Oxodihydroisoxasoles. XIV. Synthesis of 2-(1-Aryltetrazol-5-yl) propanoic Acids

D Caiazza, RH Prager, K Schafer

Index: Caiazza, Daniela; Prager, Rolf H.; Schafer, Karl Australian Journal of Chemistry, 1995 , vol. 48, # 11 p. 1861 - 1872

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Citation Number: 5

Abstract

Abstract A number of N-arylisoxazol-5 (2H)-ones (aryl= phenyl, isoquinolin-1-yl, quinolin-2- yl, 2-phenylquinazolin-4-yl and benzothiazol-2-yl) have been reacted with lithium azide to give 2-(1-aryltetrazol-5-yl) acetic esters, which have been C-methylated and hydrolysed. The resulting 2-(1-aryltetrazol-5-yl) propanoic acids had low antiinflammatory activity, as judged by inhibition of synthesis of prostaglandin PGE 2 or tumour necrosis factor α.