Eine chiral ökonomische Totalsynthese von (R)??und (S)??Muskon via Epoxysulfoncyclofragmentierung
Q Branca, A Fischli
Index: Branca,Q.; Fischli,A. Helvetica Chimica Acta, 1977 , vol. 60, p. 925 - 944
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Citation Number: 82
Abstract
Summary Starting with isobutyric acid (2) and using a microbiological oxidation with pseudomonas putida (S)-8-hydroxy-iso-butyric acid (3) has been prepared. From this ((pseudosymmetrical D (see text) intermediate the two enantiomeric bromo derivatives 8 (R) and 20 (S) have been synthesized (cf. scheme 4) by altering the sequence of the reactions (cf. scheme 3). A Grignard reaction starting from the two bromo compounds 8 and 20 and ...
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