Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators

M Pettersson, DS Johnson, C Subramanyam…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 8 p. 2906 - 2911

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Citation Number: 17

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... With more than 35 million people affected world-wide, AD represents a significant unmet medical need since no ... Using arylimidazole E2012 (1) as a starting point, 8 our medicinal chemistry strategy was focused on two primary design ...