New organocatalysts for the asymmetric reduction of imines with trichlorosilane
…, K Vranková, RC Sigerson, S Stončius, P Kočovský
Index: Malkov, Andrei V.; Vrankova, Kvetoslava; Sigerson, Ralph C.; Stoncius, Sigitas; Kocovsky, Pavel Tetrahedron, 2009 , vol. 65, # 45 p. 9481 - 9486
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Citation Number: 28
Abstract
Enantioselective reduction of prochiral ketimines, such as 1, represents an attractive route to enantiomerically enriched (or pure) amines 2 (Scheme 1), many of which serve as building blocks for the pharmaceutical and fine chemicals industry. In addition to the transition metal-catalyzed reduction 1, 1a, 1b, 1c, 1d, 1e, 1f, 1g, 2, 2a, 2b, 2c, 2d, 2e, 2f, 2g, 3, 3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h, 3i, 3j and 4 and hydrogenation, 5, 5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j, 5k, 5l and 5m a ...