Organic & biomolecular chemistry

Asymmetric hydrogenation of α-or β-acyloxy α, β-unsaturated phosphonates catalyzed by a Rh (i) complex of monodentate phosphoramidite

J Zhang, K Dong, Z Wang, K Ding

Index: Zhang, Jinzhu; Dong, Kaiwu; Wang, Zheng; Ding, Kuiling Organic and Biomolecular Chemistry, 2012 , vol. 10, # 8 p. 1598 - 1601

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Citation Number: 15

Abstract

The Rh (I) complex of a monodentate phosphoramidite bearing a primary amine moiety (DpenPhos) has been disclosed to be highly efficient for the asymmetric hydrogenation of a variety of α-or β-acyloxy α, β-unsaturated phosphonates, providing the corresponding biologically important chiral α-or β-hydroxy phosphonic acid derivatives with excellent enantioselectivities (90–> 99% ee).