Synthesis of a new ratiometric emission Ca 2+ indicator for in vivo bioimaging

QL Liu, M Fan, W Bian, SM Shuang, C Dong

Index: Liu, Qiao-Ling; Fan, Meng; Bian, Wei; Shuang, Shao-Min; Dong, Chuan Chinese Chemical Letters, 2013 , vol. 24, # 2 p. 156 - 158

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Citation Number: 3

Abstract

A novel fluorescent calcium indicator with a 490/582nm ratiometric emission has been designed and synthesized. The indicator exhibits a highly selective ratiometric emission response to Ca2+ over other metal cations and a large Stokes shift of 202nm. Moreover, its practical cell imaging capability for intracellular Ca2+ in the resting-and dynamic-state has been demonstrated in human umbilical vein endothelial cells using a confocal laser ...