Regioselective synthesis of phenanthrenes and evaluation of their anti-oxidant based anti-inflammatory potential
Y Kanekar, K Basha, S Duche, R Gupte…
Index: Kanekar, Yogesh; Basha, Khalander; Duche, Sharad; Gupte, Rajan; Kapat, Arnab European Journal of Medicinal Chemistry, 2013 , vol. 67, p. 454 - 463
Full Text: HTML
Citation Number: 4
Abstract
Abstract Regioselective synthesis of 9, 10-Dihydro-2, 5-Dimethoxyphenanthrene-1, 7-diol (1) and 9, 10-Dihydro-2, 7-Dimethoxyphenanthrene-1, 5-diol (2) was achieved using regioselective methylation, Wittig reaction, intramolecular cyclization and hydrogenation as key steps. The synthesis was successfully completed in total of 15 steps with 3.3% overall yield in case of 1 and in total of 13 steps with 9.0% overall yield in case of 2. All ...
Related Articles:
[Nawrat, Christopher C.; Palmer, Leoni I.; Blake, Alexander J.; Moody, Christopher J. Journal of Organic Chemistry, 2013 , vol. 78, # 11 p. 5587 - 5603]
Electrophilic carbon transfer in gold catalysis: synthesis of substituted chromones
[Tetrahedron Letters, , vol. 52, # 19 p. 2476 - 2479]
Synthesis of 3-methyl-5, 6-dihydro-3H-benzofuro [3, 2-e] isoquinolin-7 (7aH)-ones
[Weller, Dwight D.; Stirchak, Eugene P.; Weller, Doreen L. Journal of Organic Chemistry, 1983 , vol. 48, # 24 p. 4597 - 4605]
[Organic Letters, , vol. 12, # 8 p. 1732 - 1735]
[Bioorganic and Medicinal Chemistry Letters, , vol. 14, # 2 p. 515 - 518]