3-(Aminoalkyl)-1, 2, 3, 4-tetrahydro-5H-[1] benzopyrano [3, 4-c] pyridin-5-ones as potential anticholinergic bronchodilators

DT Connor, PC Unangst, CF Schwender…

Index: Connor; Unangst; Schwender; Sorenson; Carethers; Puchalski; Brown; Finkel Journal of Medicinal Chemistry, 1989 , vol. 32, # 3 p. 683 - 688

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Citation Number: 14

Abstract

X guinea cholinergic dog pulmonary pig collapse A: bronchospasm B: salivation selectivity compd R1 RZ X' time, minb ID,' IDwd@/A) 4a Me0 Me0 A 4.9 f 1.2---4b Me0 Me0 B 4.0 f 1.3--- 4ce Me0 Me0 A 1.6 f 0.1---4d Me0 HA 9.5 f 0.4 205 141 0.69 4e Me0 HB 8.0 f 1.4 223 398 1.8 4f Me0 HC 1.9 f 0.1 4g Me0 HD 8.0 f 1.3 394 158 0.40 4h Me0 HE 7.0 f 1.4 428 855 2.0 4i Me0 HF 9.1 f 1.0 246 735 3.0 4j Me0 HG 6.1 f 1.8 1141 714 0.63 4k Me0 Me0 H 2.8 f 0.4 ...