Non-steroidal glucocorticoid-like substances: receptor binding and in vivo activity

…, JR Wetzel, JL Herrmann, R McGarry…

Index: Kumar, Virendra; Bell, Malcolm R.; Wetzel, Joseph R.; Herrmann, John L.; McGarry, Ruthan; et al. Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3278 - 3285

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Citation Number: 4

Abstract

0 Reagents:(a) HCOZMe, NaOMe, Eh0;(b) HOAc, KOAc, 4-pyridylNHNH2;(c) NJV- dimethylalloxan, A, xylenes. the basis of lH NMR and NOE experiments. Irradiation of (2-10 methyl group resulted in 10-15% enhancement of C-11 proton16 signal intensity for both the compounds. However, no enhancement of C-8 proton signal was observed for 12a. In contrast 12b showed an 11% enhancement of C-8 proton thus providing the ...