Journal of medicinal chemistry

Synthesis, structure− affinity relationships, and radiolabeling of selective high-affinity 5-HT4 receptor ligands as prospective imaging probes for positron emission …

R Xu, J Hong, CL Morse, VW Pike

Index: Xu, Rong; Hong, Jinsoo; Morse, Cheryl L.; Pike, Victor W. Journal of Medicinal Chemistry, 2010 , vol. 53, # 19 p. 7035 - 7047

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Citation Number: 12

Abstract

In a search for high-affinity receptor ligands that might serve for development as radioligands for the imaging of brain 5-HT4 receptors in vivo with positron emission tomography (PET), structural modifications were made to the high-affinity 5-HT4 antagonist (1-butylpiperidin-4-yl) methyl 8-amino-7-iodo-2, 3-dihydrobenzo [b][1, 4] dioxine-5- carboxylate (1, SB 207710). These modifications were made mainly on the aryl side of the ...