Chemical characterization of bonded stationary phases for high-performance liquid chromatography using hydrofluoric acid digestion and gas chromatography

SD Fazio, SA Tomellini, SH Hsu, JB Crowther…

Index: Fazio, Steven D.; Tomellini, Sterling A.; Shih-Hsien, Hsu; Crowther, Jonathan B.; Raglione, Thomas V.; et al. Analytical Chemistry, 1985 , vol. 57, p. 1559 - 1564

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Citation Number: 34

Abstract

A simple and accurate bench top method is presented for the analysis of chemically bonded reversed-phase (Cl, C8, C18) HPLC packing materials, based on HF digestion and analysis by capillary or packed column GC. Bonded silanes of six carbon atoms or more are analyzed by hexane extraction and GC, while the more volatile trimethyisllane “capping” silanes are analyzed by a headspace technique. Overall analysis time is 2-3 h digestlon ...