Synthesis, pharmacological evaluation and docking studies of coumarin derivatives

…, V Mathew, G Basavarajaswamy, R Abraham

Index: Sandhya; Giles; Mathew, Vinod; Basavarajaswamy, Guru; Abraham, Rekha European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 4696 - 4701

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Citation Number: 21

Abstract

We synthesized coumarin derivatives using various aromatic and heterocyclic amines, and tested the target compound for its analgesic, anti-inflammatory, antimicrobial activities. Compounds 3l, 3m and 3n showed significant anti-inflammatory, analgesic and antimicrobial activities. The synthesized compounds, then docked on COX-2 to predict the binding affinity and orientation at the active site of the receptor. It was found that the active ...