Getting Ring??Closing Metathesis off the Bench: Reaction??Reactor Matching Transforms Metathesis Efficiency in the Assembly of Large Rings

S Monfette, M Eyholzer, DM Roberge…

Index: Monfette, Sebastien; Eyholzer, Markus; Roberge, Dominique M.; Fogg, Deryn E. Chemistry - A European Journal, 2010 , vol. 16, # 38 p. 11720 - 11725

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Citation Number: 21

Abstract

Abstract Reported is the first study of the influence of reactor configuration on the efficiency of a challenging ring-closing metathesis (RCM) reaction. With the intention of increasing the generality of RCM scaleup and reducing its dependence on substrate modification, macrocyclization of an unmodified, low effective-molarity diene was explored using different reactor types, in conjunction with a commercial, homogeneous Grubbs catalyst. Optimized ...