Tetrahedron Letters

Novel supported and unsupported prolinamides as organocatalysts for enantioselective cyclization of triketones

R Pedrosa, JM Andrés, R Manzano, C Pérez-López

Index: Pedrosa, Rafael; Andres, Jose Maria; Manzano, Ruben; Perez-Lopez, Cesar Tetrahedron Letters, 2013 , vol. 54, # 24 p. 3101 - 3104

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Citation Number: 10

Abstract

A novel prolylsulfonamide derived from ethylene diamine and its supported counterpart has been prepared and tested as enantioselective intramolecular aldol reaction of cyclic and acyclic triketones. Good to excellent yields and enantioselectivities have been obtained in water and under solvent free conditions.