Synthèse et activité antithyroïdienne de dérivés du triazole

JF Lagorce, F Comby, J Buxeraud, C Raby

Index: Lagorce; Comby; Buxeraud; Raby European Journal of Medicinal Chemistry, 1992 , vol. 27, # 4 p. 359 - 368

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Citation Number: 10

Abstract

Abstract The synthesis of nitrogen heterocycle derivatives (pyridine, pyrimidine, pyrazine) of 3-mercapto-1, 2, 4-triazole and 3-mercapto-1-methyl-1, 2, 4-triazole is described. The antithyroid activity of compounds is evaluated by action on molecular iodine, by action on peroxidase and in vivo on the rat (hormones levels, histology). Pyridyl and pyrimidyl derivatives of mercaptotriazole and mercaptomethyltriazole, as well as (6-methoxy-pyridyl) ...