Chloroperoxidase and hydrogen peroxide: An efficient system for enzymatic enantioselective sulfoxidations.

S Colonna, N Gaggero, L Casella, G Carrea…

Index: Colonna; Gaggero; Casella; Carrea; Pasta Tetrahedron Asymmetry, 1992 , vol. 3, # 1 p. 95 - 106

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Citation Number: 165

Abstract

Abstract High enantioselectivities were obtained in chloroperoxidase catalyzed oxidation of organic sulfides (99% ee in the case of methyl 2-pyridyl sulfide) with H 2 O 2 in aqueous buffer solution, pH 5, at 25 C. The kinetic parameters in the oxidation of a series of sulfides both with H 2 O 2 and tert-butyl hydroperoxide were determined and the data are consistent with enzymatic oxidation involving presumably a ternary complex, in all cases the reaction ...