Metabolic N-hydroxylation. Use of substituent variation to modulate the in vitro bioactivation of 4-acetamidostilbenes
PE Hanna, RE Gammans, RD Sehon…
Index: Hanna, Patrick E.; Gammans, Richard E.; Sehon, Russell D.; Lee, Man-Kil Journal of Medicinal Chemistry, 1980 , vol. 23, # 9 p. 1038 - 1044
Full Text: HTML
Citation Number: 16
Abstract
N-Hydroxylation is an obligate step in the bioactivation of carcinogenic aryl amides. Previous reports from this laboratory demonstrated that variation of the 4'substituent of trans- 4-acetamidostilbene (1) has a marked effect on the rate of its in vitro microsomal N- hydroxylation. In order to further investigate the effects of electronegative and aliphatic substituents, the 4'-CN, 4'-CH,, 4'-C (CH3),, and 4'-CF3 analogues of 1 were synthesized ...
Related Articles:
Catalytic activity of Pd (II) and Pd (II)/DAB-R systems for the Heck arylation of olefins
[Grasa, Gabriela A.; Singh, Rohit; Stevens, Edwin D.; Nolan, Steven P. Journal of Organometallic Chemistry, 2003 , vol. 687, # 2 p. 269 - 279]
[Bose, Rohit; Ahmad, Abid R.; Dicks, Andrew P.; Novak, Michael; Kayser, Kelly J.; McClelland, Robert A. Journal of the Chemical Society. Perkin Transactions 2, 1999 , # 8 p. 1591 - 1599]
[Bose, Rohit; Ahmad, Abid R.; Dicks, Andrew P.; Novak, Michael; Kayser, Kelly J.; McClelland, Robert A. Journal of the Chemical Society. Perkin Transactions 2, 1999 , # 8 p. 1591 - 1599]
[Fang, Zhengjun; Cao, Chenzhong; Chen, Guanfan Journal of Physical Organic Chemistry, 2012 , vol. 25, # 12 p. 1343 - 1350]