Synthetic applications of 2??chlorotetrahydrofuran: Protection of alcohols as tetrahydro??2??furanyl (THF) ethers

CG Kruse, FL Jonkers, V Dert…

Index: Kruse,C.G. et al. Recueil des Travaux Chimiques des Pays-Bas, 1979 , vol. 98, p. 371 - 380

Full Text: HTML

Citation Number: 36

Abstract

Abstract 2-Chlorotetrahydrofuran (2-Cl-THF) is formed in 85% yield by reaction of sulfuryl chloride with excess THF. 2-Cl-THF reacts with alcohols, phenols, acids, thiols, azoles, amides and imides to give the corresponding tetrahydro-2-furanyl derivatives. Reaction with uracil derivatives provides N 1-and N 3-monosubstituted and N 1, N 3-disubstituted compounds. The reaction with alcohols provides a convenient general procedure for ...