A domino copper-catalyzed CO coupling-Claisen rearrangement process

G Nordmann, SL Buchwald

Index: Nordmann, Gero; Buchwald, Stephen L. Journal of the American Chemical Society, 2003 , vol. 125, # 17 p. 4978 - 4979

Full Text: HTML

Citation Number: 159

Abstract

A practical method for the diastereoselective generation of two adjacent quarternary stereocenters by combining a copper-catalyzed CO coupling reaction with a subsequent Claisen rearrangement in a one-pot domino process is described. Furthermore, an experimentally simple method for the stereoselective synthesis of a variety of different types of vinyl ethers is delineated using the same catalyst system.

Related Articles:

Intra-and intermolecular 1, 3-dipolar cycloaddition of sugar ketonitrones with mono-, di-, and trisubstituted dipolarophiles

[Torrente, Susana; Noya, Beatriz; Branchadell, Vicenc; Alonso, Ricardo Journal of Organic Chemistry, 2003 , vol. 68, # 12 p. 4772 - 4783]

Benzyl Enol Ethers via Decarboxylation of α-Benzyloxy-β-lactones Derived from the Lithium α-Benzyloxy-α-lithioacetate Synthon

[Adam,W.; Arias Encarnacion,L.A. Synthesis, 1979 , p. 388 - 390]

Benzyl Enol Ethers via Decarboxylation of α-Benzyloxy-β-lactones Derived from the Lithium α-Benzyloxy-α-lithioacetate Synthon

[Adam,W.; Arias Encarnacion,L.A. Synthesis, 1979 , p. 388 - 390]

Benzyl Enol Ethers via Decarboxylation of α-Benzyloxy-β-lactones Derived from the Lithium α-Benzyloxy-α-lithioacetate Synthon

[Adam,W.; Arias Encarnacion,L.A. Synthesis, 1979 , p. 388 - 390]

More Articles...