The o-amino-trifluoromethyl functionality as a novel synthon for 4-fluoroquinolines

L Strekowski, AS Kiselyov, M Hojjat

Index: Strekowski, Lucjan; Kiselyov, Alexander S.; Hojjat, Maryam Journal of Organic Chemistry, 1994 , vol. 59, # 20 p. 5886 - 5890

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Citation Number: 45

Abstract

The trifluoromethyl group in 2-(trifluor0methy) aniline (11, its para isomer, and heteroaromatic analogs exhibits unusual reactivity under basic conditions that cause ionization of the amino The CF3 group in such substrates is easily hydrolyzed to a carboxylate group in the presence of hydroxide base and transformed into a carbonitrile function in an amide ion mediated reaction. lS2 Recently, the anionically activated CF3 ...