Synthesis of protected 4-demethoxy-8-nordaunomycinone

…, KT Stewart, DL Wenstrup, DW Beight…

Index: Flynn, Gary A.; Vaal, Mark J.; Stewart, Kenneth T.; Wenstrup, David L.; Beight, Douglas W.; Bohme, Ekkehard H. Journal of Organic Chemistry, 1984 , vol. 49, # 12 p. 2252 - 2258

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Citation Number: 6

Abstract

The clinical utility of anthracycline antibiotics' such as daunomycin 1 has prompted varied approaches to their synthesis2 and derivatization. The major thrust in analogue development has been to diminish the cumulative cardiotoxic liability of these antitumor agentsS3 Deletion of the 4-methoxyl group in daunomycin has resulted in increased poten~ y.~ With these thoughts in mind, the