Generation and reactions of o-bromophenyllithium without benzyne formation using a microreactor

…, H Okamoto, T Nokami, J Yoshida

Index: Usutani, Hirotsugu; Tomida, Yutaka; Nagaki, Aiichiro; Okamoto, Hideho; Nokami, Toshiki; Yoshida, Jun-Ichi Journal of the American Chemical Society, 2007 , vol. 129, # 11 p. 3046 - 3047

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Citation Number: 180

Abstract

Microflow systems were found to serve as powerful tools for mechanistic studies on reactions involving highly unstable intermediates such as o-bromophenyllithium, which is known to decompose to benzyne very quickly even at-78° C. Precise residence time control and precise temperature control of microsystems are responsible. Based on the information thus obtained, the Br-Li exchange reaction of o-dibromobenzene followed by reactions ...

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Stille coupling involving bulky groups feasible with gold cocatalyst

Generation and reactions of o-bromophenyllithium without benzyne formation using a microreactor

Abstract

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