Tetrahedron Letters

An efficient catalytic method for the Friedländer annulation mediated by peptide coupling agent propylphosphonic anhydride (T3P®)

JK Augustine, A Bombrun, S Venkatachaliah

Index: Augustine, John Kallikat; Bombrun, Agnes; Venkatachaliah, Srinivasa Tetrahedron Letters, 2011 , vol. 52, # 50 p. 6814 - 6818

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Citation Number: 21

Abstract

We have demonstrated the utilization of T3P, a mild and low toxic peptide coupling agent, as a promoter and water scavenger in the Friedländer annulation, and thus introduced a highly efficient catalytic process to access carbocyclic and heterocyclic fused quinolines under microwave irradiation or a conventional heating technique. The reaction conditions are sufficiently mild to tolerate the acid and base sensitive functional groups that can serve as ...