Synthesis of pelorol and analogues: activators of the inositol 5-phosphatase SHIP
…, C Ong, G Krystal, R van Soest, RJ Andersen
Index: Yang, Lu; Williams, David E.; Mui, Alice; Ong, Christopher; Krystal, Gerald; Van Soest, Rob; Andersen, Raymond J. Organic Letters, 2005 , vol. 7, # 6 p. 1073 - 1076
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Citation Number: 57
Abstract
A screening program designed to find new antiinflammatory agents has identified the sponge meroterpenoid pelorol (1) as an in vitro activator of the inositol-5-phosphatase SHIP. Pelorol (1) and several functional group analogues have been synthesized from sclareolide (4).
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