Potent antimicrobial activity of 3-(4, 5-diaryl-1H-imidazol-2-yl)-1H-indole derivatives against methicillin-resistant Staphylococcus aureus

RA Al-Qawasmeh, M Huesca, V Nedunuri…

Index: Al-Qawasmeh, Raed A.; Huesca, Mario; Nedunuri, Venkata; Peralta, Robert; Wright, Jim; Lee, Yoon; Young, Aiping Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 12 p. 3518 - 3520

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Citation Number: 16

Abstract

A new series of antimicrobial derivatives [3-(4, 5-diaryl-1H-imidazol-2-yl)-1H-indole)] have been synthesized with potent activity against strains of Staphylococcus aureus, including methicillin-resistant strains (MRSA). Compound 17 [3-(4, 5-bis (4-fluorophenyl)-1H-imidazol- 2-yl)-5-bromo-1H-indole], the most active derivative was shown to inhibit the growth of all Gram-positive strains tested, including vancomycin resistant Enterococcus faecalis and ...