Deoxy sugar analogues of triciribine: correlation of antiviral and antiproliferative activity with intracellular phosphorylation

…, KZ Borysko, JM Breitenbach, S Vittori…

Index: Porcari, Anthony R.; Ptak, Roger G.; Borysko, Katherine Z.; Breitenbach, Julie M.; Vittori, Sauro; Wotring, Linda L.; Drach, John C.; Townsend, Leroy B. Journal of Medicinal Chemistry, 2000 , vol. 43, # 12 p. 2438 - 2448

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Citation Number: 25

Abstract

Triciribine (TCN) and triciribine monophosphate (TCN-P) have antiviral and antineoplastic activity at low micromolar or submicromolar concentrations. In an effort to improve and better understand this activity, we have conducted a structure-activity relationship study to explore requirements for the number of hydroxyl groups on the ribosyl moiety for biological activity. 2'- Deoxytriciribine (2'-dTCN), 3'-deoxytriciribine (3'-dTCN), 2', 3'-epoxytriciribine (2', 3'- ...