Synthesis, antimalarial, antileishmanial, antimicrobial, cytotoxicity, and methemoglobin (MetHB) formation activities of new 8-quinolinamines

…, P Patil, M Jain, SI Khan, MR Jacob, S Ganesan…

Index: Kaur, Kirandeep; Patel, Sanjay R.; Patil, Premanand; Jain, Meenakshi; Khan, Shabana I.; Jacob, Melissa R.; Ganesan, Shobana; Tekwani, Babu L.; Jain, Rahul Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 915 - 930

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Citation Number: 38

Abstract

We report the synthesis, in vitro antiprotozoal (against Plasmodium and Leishmania), antimicrobial, cytotoxicity (Vero and MetHb-producing properties), and in vivo antimalarial activities of two series of 8-quinolinamines. N1-{4-[2-(tert-Butyl)-6-methoxy-8-quinolylamino] pentyl}-(2S/2R)-2-aminosubstitutedamides (21–33) and N1-[4-(4-ethyl-6-methoxy-5- pentyloxy-8-quinolylamino) pentyl]-(2S/2R)-2-aminosubstitutedamides (51–63) were ...