Carbohydrate Research

Some applications of the Knoevenagel reaction in the carbohydrate field

FJL Aparicio, FJL Herrera, JS Ballesteros

Index: Aparicio,F.J.L. et al. Carbohydrate Research, 1979 , vol. 69, p. 55 - 70

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Citation Number: 15

Abstract

Abstract The reaction of 2-3-O-isopropylidene-d-glyceraldehyde (1) with active methylene compounds in the absence of a catalyst involves facile and reversible addition to the formyl group. The adducts are readily transformed into furan derivatives by acid hydrolysis. When the reaction is catalysed with piperidine, unsaturated products are also formed, including α, β-and β, γ-unsaturated dicarbonyl compounds, which are transformed into furan ...