Potent benzimidazole sulfonamide protein tyrosine phosphatase 1B inhibitors containing the heterocyclic (S)-isothiazolidinone phosphotyrosine mimetic
AP Combs, W Zhu, ML Crawley, B Glass…
Index: Journal of Medicinal Chemistry, , vol. 49, # 13 p. 3774 - 3789
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Citation Number: 77
Abstract
... Journal of Medicinal ... 2,3 Thus, a potent cell permeable inhibitor of PTP1B has been sought by nearly all pharmaceutical companies to test ... 4. Medicinal chemistry efforts to date have focused on the identification of inhibitors that contain strong binding, nonhydrolysable tyrosine ...
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[Combs, Andrew P.; Zhu, Wenyu; Crawley, Matthew L.; Glass, Brian; Polam, Padmaja; Sparks, Richard B.; Modi, Dilip; Takvorian, Amy; McLaughlin, Erin; Yue, Eddy W.; Wasserman, Zelda; Bower, Michael; Wei, Min; Rupar, Mark; Ala, Paul J.; Reid, Brian M.; Ellis, Dawn; Gonneville, Lucie; Emm, Thomas; Taylor, Nancy; Yeleswaram, Swamy; Li, Yanlong; Wynn, Richard; Burn, Timothy C.; Hollis, Gregory; Liu, Phillip C. C.; Metcalf, Brian Journal of Medicinal Chemistry, 2006 , vol. 49, # 13 p. 3774 - 3789]
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