Synthesis and in vitro cysticidal activity of new benzimidazole derivatives

…, S Rodríguez-Morales, G Palencia-Hernández…

Index: Palomares-Alonso, Francisca; Jung-Cook, Helgi; Perez-Villanueva, Jaime; Piliado, Juan Carlos; Rodriguez-Morales, Sergio; Palencia-Hernandez, Guadalupe; Lopez-Balbiaux, Nayeli; Hernandez-Campos, Alicia; Castillo, Rafael; Hernandez-Luis, Francisco European Journal of Medicinal Chemistry, 2009 , vol. 44, # 4 p. 1794 - 1800

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Citation Number: 24

Abstract

Despite albendazole being the drug of choice in neurocysticercosis treatment, its low solubility limits its bioavailability; therefore, more research is required in order to find new molecules with cestocidal activity and adequate aqueous solubility. A set of 13 benzimidazole derivatives were synthesized and their in vitro activities were evaluated against Taenia crassiceps cysts, using albendazole sulfoxide as reference molecule, ...